Using Parallels and BootCamp will allow you to run Windows in macOS and also boot directly to Windows for more resource intense tasks. The size of the virtual partition can be adjusted as needed but you will always have to use a virtual machine. Parallels can be set up one of two ways, the standard virtual partition or from BootCamp.

You can even set it up so that you can run the individual apps instead of using a full Windows desktop. Parallels is nice because it will let you run macOS and Windows at the same time. AutoCAD for Mac is not a direct port and the Windows version is what you’ll encounter out in the world. If you really want to use AutoCAD then run it in Windows. You should really consider using Revit instead of AutoCAD.